Ion Channel Assays

GluR2 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

GluR2 - QPatch

GluR2 assay

Figure 1:  Concentration dependent effect of agonist Glutamate (+CTZ)  on HEK-293 cells stably transfected with GluR2.  Calculated EC50 value 11 µM.

GluR2 - QPatch

GluR2 assay

Figure 2: Concentration dependent effect of antagonist YM-90K on HEK-293 cells stably transfected with GluR2 (activated with Glutamate 10 μM + CTZ 50 μM). Calculated IC50 value 0.25 μM.


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