GABA receptor assays

GABAA Receptor Screening Services

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GABAA receptors are ligand-gated ion channels which respond to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). There are many subunit isoforms for the GABAA receptor of which 5 are required to make up a functional channel (usually 2 α's, 2 β's and a single γ). Subunit composition plays a role in agonist affinity and varies depending on the region of the brain.

SB Drug Discovery offers a comprehensive panel of GABAA assays for HTS, lead optimization studies and selectivity profiling. Our assays have been validated by experienced in-house electrophysiologists using rigorously optimized SOPs to ensure data of the highest quality and consistency.

To discuss your next ion channel project or to receive a quote, visit our contact page or call +44 141 587 6100.

GABAA receptor assays

Channel Species Fluorescence Assay Electrophysiology Assay
α1β1γ2 Human Green Dot Green Dot
α2β1γ2 Human Green Dot Green Dot
α3β1γ2 Human Green Dot Green Dot
α4β1γ2 Human Green Dot Green Dot
α5β1γ2 Human Green Dot Green Dot
α6β1γ2 Human Green Dot Orange Dot
α1β2γ2 Human Green Dot Green Dot
α2β2γ2 Human Green Dot Orange Dot
α3β2γ2 Human Green Dot Orange Dot
α5β2γ2 Human Green Dot Orange Dot
α6β2γ2 Human Green Dot Orange Dot
α1β3γ2 Human Green Dot Orange Dot
α2β3γ2 Human Green Dot Green Dot
α3β3γ2 Human Green Dot Orange Dot
α4β3γ2 Human Green Dot Orange Dot
α4β3δ Human Green Dot Green Dot