Glutamate Receptor Screening Assays
Ionotropic glutamate receptors are ligand-gated ion channels which are activated by the neurotransmitter glutamate. Ionotropic glutamate receptors can be divided into 4 subgroups (NMDA, AMPA, kainate and delta receptors), based on their pharmacology and sequence similarity. Ionotropic glutamate receptors mediate excitatory synaptic transmission throughout the CNS and are involved in the synaptic plasticity of learning and memory.
SB Drug Discovery has developed stable glutamate receptor cell lines and validated screening & profiling assays for HTS, lead optimization studies and selectivity profiling. Our assays have been validated by experienced in-house electrophysiologists using rigorously optimized SOPs to ensure data of the highest quality and consistency.
NMDA Selectivity Assays
NMDA Assays: Screen compounds against individual NMDA subtypes or profile for selectivity across all NMDA receptors.
AMPA Screening Assay
AMPA screening: Screen compounds against the AMPA receptor GluR2 using fluorescence-based FLIPR technology.
NMDA receptor electrophysiology: High throughput electrophysiology assays available for assessment of glutamate receptor agonists, antagonists and allosteric modulators.
Glutamate Receptor Assays
|NMDA NR1/2A||NMDA NR1/2B||NMDA NR1/2C||NMDA NR1/2D|
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