Glutamate Receptors

Glutamate Receptors

Glutamate Receptors

Ionotropic glutamate receptors are ligand-gated ion channels which are activated by the neurotransmitter glutamate. Ionotropic glutamate receptors can be divided into 4 subgroups (NMDA, AMPA, kainate and delta receptors), based on their pharmacology and sequence similarity. Ionotropic glutamate receptors mediate excitatory synaptic transmission throughout the CNS and are involved in the synaptic plasticity of learning and memory.

SB Drug Discovery has developed stable glutamate receptor cell lines and validated screening & profiling assays for HTS, lead optimization studies and selectivity profiling. Our assays have been validated by experienced in-house electrophysiologists using rigorously optimized SOPs to ensure data of the highest quality and consistency.

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Glutamate Receptors

Channel Species Fluorescense Assay Electrophysiology Assay
GluN1/2A Human Green Dot Green Dot
GluN1/2B Human Green Dot Green Dot
GluN1/2C Human Green Dot Green Dot
GluN1/2D Human Green Dot Green Dot
GluA2 Human Green Dot Green Dot