GPCR assays

Cannabinoid Receptor Assays

Species: Human

Subtypes: CB1, CB2

Assay Formats: Radioligand binding (CB1, CB2), Cell-based assay (CB1, CB2)

Services: HTS, single concentration / dose response studies, selectivity profiling

 

Cannabinoid CB1 - Cell-based assay

Cannabinoid CB1 cell based assay

Figure 1: Dose response curve for agonist CB13 in a Cannabinoid CB1 cell-based assay. Approximate EC50 6.9 μM.

 

Cannabinoid CB1 - Cell-based assay

Cannabinoid CB1 cell based assay

Figure 2: Dose response curve for antagonist AM281 in a Cannabinoid CB1 cell-based assay. Approximate IC50 0.68 μM.

 

Cannabinoid CB2 - Cell-based assay

Cannabinoid CB2 cell based assay

Figure 3: Dose response curve for agonist SER601 in a Cannabinoid CB2 cell-based assay. Approximate EC50 349 nM.

 

Cannabinoid CB2 - Cell-based assay

Cannabinoid CB2 cell based assay

Figure 4: Dose response curve for antagonist AM630 in a Cannabinoid CB2 cell-based assay. Approximate IC50 109 nM.


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