GPCR assays

Dopaminergic Receptor Assays

Species: Human

Subtypes: D1, D2, D3, D4 (others available on request)

Assay Formats: Radioligand binding (D1, D2, D3, D4), Cell-based assay (D1, D2)

Services: HTS, single concentration / dose response studies, selectivity profiling

 

Dopaminergic D1 - Ligand binding assay

Dopamine D1 binding assay

Figure 1: Dose response curve for Clozapine in a Dopaminergic D1 radioligand binding assay. Approximate IC50 58nM.

 

Dopaminergic D2 - Ligand binding assay

Dopamine D2 binding assay

Figure 2: Dose response curve for Clozapine in a Dopaminergic D2 radioligand binding assay. Approximate IC50 178nM.

 

Dopaminergic D3 - Ligand binding assay

Dopamine D3 binding assay

Figure 3: Dose response curve for Clozapine in a Dopaminergic D3 radioligand binding assay. Approximate IC50 153nM.

 

Dopaminergic D4 - Ligand binding assay

Dopamine D4 binding assay

Figure 4: Dose response curve for Clozapine in a Dopaminergic D4 radioligand binding assay. Approximate IC50 49nM.

 

Dopaminergic D1 - Cell-based assay

Dopamine D1 cell based assay

Figure 5: Dose response curve for agonist Dopaminergic in a D1 cell-based assay. Approximate EC50 44 nM.

 

Dopaminergic D1 - Cell-based assay

Dopamine D1 cell based assay

Figure 6: Dose response curve for antagonist Clozapine in a Dopaminergic D1 cell-based assay. Approximate IC50 9 nM.

 

Dopaminergic D2 - Cell-based assay

Dopamine D2 cell based assay

Figure 7: Dose response curve for agonist Dopaminergic in a D2 cell-based assay. Approximate EC50 156 nM.

 

Dopaminergic D2 - Cell-based assay

Dopamine D2 cell based assay

Figure 8: Dose response curve for antagonist Clozapine in a Dopaminergic D2 cell-based assay. Approximate IC50 489 nM.


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