GPCR Services

GPCR Services

Radioligand binding & cell-based GPCR assays.

SB Drug Discovery's GPCR assays enable the evaluation of binding and downstream effects of small molecules against a wide variety of GPCR targets. Our assays employ radioligand binding, GTPγS and whole-cell calcium assays in order to investigate affinity and nature of binding.

Using radioligand binding to determine binding affinity and whole-cell or GTPγS assays to distinguish between agonists, antagonists and allosteric modulators, SB can perform HTS, dose-response studies and selectivity profiling against a broad panel of GPCR targets.

Need a GPCR cell line? Trust SB's experienced Cell Line Development team to deliver a cell line that fits your exact screening requirements.

GPCR Assays

AdoR

A1, A2a

Adrenergic

α1A, α1B, α2A, α2C, β1, β2

Bradykinin

B2

Cannabinoid

CB1, CB2

Cholecystokinin

CCK1

Dopamine

D1, D2, D3, D4

Endothelin

ET1

GHS-R

GHS-R

Histamine

H1, H2

Muscarinic

M1, M2, M3, M4, M5

Opioid

δ-, κ-, μ-opioid

P2Y

P2Y2

PAR

PAR2, PAR4

Serotonin (5HT)

5HT1A, 2A, 2B, 2C, 6, 7

Smoothened

Smo1

Vasopressin

V1a

Other GPCR targets available on request.


Cell Line Development
Safety Assessment