GPCR safety panel

GPCR Safety Assessment Screening

Reducing costly safety-related attrition.

Identification of undesirable off-target effects is an essential process in any drug discovery campaign. In vitro pharmacological profiling against a broad panel of known potential hazards at an early stage in the discovery process can therefore aid decision-making in lead generation, lead optimization and candidate selection, resulting in significantly reduced downstream safety-related attrition.

SB’s GPCR safety assessment panel provides a broad pharmacological profile of your compounds and their potential to cause adverse drug reactions. Our flexible service allows you to screen against the complete panel or select only the targets that matter to you.

GPCR Safety Panel

Receptor Species Ligand Binding Cell-Based Assay
5HTR1A Human Green Dot Green Dot
5HTR1B Human   Green Dot
5HTR2A Human Green Dot Green Dot
5HTR2B Human   Green Dot
ADOR A2a Human Green Dot Green Dot
ADRA1A Human Green Dot Green Dot
ADRA2A Human Green Dot Green Dot
ADRB1 Human   Green Dot
ADRB2 Human   Green Dot
CCKAR Human   Green Dot
CHRM1 Human Green Dot Green Dot
CHRM2 Human Green Dot Green Dot
CHRM3 Human Green Dot Green Dot
CNR1 Human Green Dot Green Dot
CNR2 Human Green Dot Green Dot
DRD1 Human Green Dot Green Dot
DRD2 Human Green Dot Green Dot
EDNRA Human   Green Dot
HR1 Human   Green Dot
HR2 Human   Green Dot
OPRD1 Human   Green Dot
OPRK1 Human   Green Dot
OPRM1 Human   Green Dot
VPR1A Human   Green Dot

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