Potassium Channel Assays

KCa1.1 (BK) Screening Assays

Species: Human

Subunits / Accessory Proteins: β4 subunit

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, Automated Electrophysiology

Services: HTS, single concentration / dose response studies, selectivity profiling

KCa1.1 - Automated Electrophysiology

kca1.1 assay

Figure 1: Superimposed KCa1.1 currents and voltage traces during application of cumulative concentrations of TEA.

KCa1.1 - Automated Electrophysiology

kca1.1 assay

Figure 2: Concentration-dependent effect of TEA on normalised KCa1.1 currents. Calculated IC50 approximately 380 µM.


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