Potassium Channel Assays

KCa2.1 (SK1) Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

KCa2.1 - Manual Patch Clamp

kca2.1 assay

Figure 1: Concentration dependent effect of agonist NS-309 on HEK 293 cells stably transfected with SK1 channel.  Calculated EC50 value 3.5 μM.

KCa2.1 - Manual Patch Clamp

kca2.1 assay

Figure 2: Concentration dependent effect of antagonist Apamin on the SK1 currents activated by internal Ca2+. Calculated IC50 value 3 nM.


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