Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

KCa2.2 - Manual Patch Clamp

Figure 1: Concentration dependent effect of agonist NS-309 on HEK 293 cells stably transfected with SK2 channels.  Calculated EC₅₀ value 6 μM.

KCa2.2 - Manual Patch Clamp

Figure 2: Effect of antagonist Apamin on SK2 currents activated by internal Ca²⁺. Calculated IC₅₀ value 0.3 nM.