Potassium Channel Assays

KCa3.1 (SK4) Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

KCa3.1 - Manual Patch Clamp

kca3.1 assay

Figure 1: Concentration dependent effect of agonist NS-309 on HEK 293 cells stably transfected with SK4 channels.  Calculated EC50 value 6.5 μM.

KCa3.1 - Manual Patch Clamp

kca3.1 assay

Figure 2: Effect of antagonist TRAM-34 on SK4 currents activated by internal Ca2+. Calculated IC50 value 79 nM.


Back to Family
Request a Screening Quote