Potassium Channel Assays

Kir2.1 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

Kir2.1 - QPatch

kir2.1 assay

Figure 1: Superimposed current-voltage traces from Kv2.1 expressing cells showing concentration-dependent block induced by ML-133.

Kir2.1 - QPatch

kir2.1 assay

Figure 2: Concentration-dependent effect of ML-133 on normalised currents (I/Imax) obtained from cells stably expressing Kir2.1 channels. Calculated IC50 10 µM .

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