Potassium Channel Assays

Kir4.1 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

Kir4.1 - QPatch

Kir4.1 assay

Figure 1: Representative example of a plotted time-course experiment (current versus time) showing the effect of increasing concentrations of BaCl2 on peak inward potassium currents.

Kir4.1 - QPatch

Kir4.1 assay

Figure 2: Concentration-dependent effects of BaCl2 on normalised currents (I/Imax) obtained from HEK-293 cells expressing Kir4.1 channels. Calculated IC50 23 µM.

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