Potassium Channel Assays

Kv11.1 (hERG) Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

hERG - Manual Patch Clamp

herg assay

Figure 1: Normalised concentration-response curve of antagonist cisapride against the hERG current activated by voltage. Calculated IC50 17 nM.

hERG - Manual Patch Clamp

herg assay

Figure 2: Normalised concentration-response curve of antagonist terfenadine against the hERG current activated by voltage. Calculated IC50 12 nM.


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