Potassium Channel Assays

Kv2.1 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

 

Kv2.1 - QPatch

Kv2.1 assay

Figure 1: Current-Voltage relationship of activation and inactivation curves of Kv2.1 (open symbols) and Kv2.1/9.3 channels (solid symbols).

 

Kv2.1 - QPatch

Kv2.1 assay

Figure 2: Concentration-dependent effect of 4-AP on currents obtained from cells stably expressing Kv2.1 and Kv2.1/9.3. Calculated IC50s were 0.57  mM and 9 mM respectively.


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