Potassium Channel Assays

Kv4.3 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

Kv4.3 - Manual Patch Clamp

Kv4.3 assay

Figure 1:  Traces from HEK-293 cells stably transfected with Kv4.3. Currents were elicited by depolarising voltage-clamp pulses from -80 mV to +50 mV, in 10 mV increments from a holding potential of -80 mV.

Kv4.3 - Manual Patch Clamp

Kv4.3 assay

Figure 2: Concentration dependent effect of antagonist Bupivacaine on HEK-293 cells stably transfected with Kv4.3. Calculated IC50 89 μM.


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