Potassium Channel Assays

Kv7.1/minK Screening Assays

Species: Human

Subunits / Accessory Proteins: minK

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

KCNQ1/E1 - QPatch

KCNQ1/E1 assay

Figure 1: Representative superimposed current-voltage traces from a cell stably transfected with Kv7.1/minK.

KCNQ1/E1 - QPatch

KCNQ1/E1 assay

Figure 2: Concentration dependent effect of antagonist XE-991 on HEK-293 cells stably transfected with Kv7.1/minK.  Calculated IC50 5 μM.

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