Potassium Channel Assays

Kv7.2/7.3 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

Kv7.2/7.3 - QPatch

KCNQ2/3 assay

Figure 1: Concentration dependent effect of agonist Retigabine on cells expressing KCNQ2/3.  Calculated EC50 value 2 μM.

Kv7.2/7.3 - QPatch

KCNQ2/3 assay

Figure 2: Concentration dependent effect of antagonist XE-991 on cells expressing KCNQ2/3.  Calculated IC50 5 μM.


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