nAChR assay

nAChR α4β2 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: FLIPR, Automated Patch Clamp

Services: HTS, single concentration / dose response studies, selectivity profiling

nAChR α4β2 - Fluorescence Assay

nAChR alpha4beta2 assayFigure 1: EC50 plot showing increasing concentrations of agonist in a FLIPR assay (approximate EC50 value 1.1 μM).

nAChR α4β2 - Fluorescence Assay

nAChR alpha4beta2 assayFigure 2: IC50 plot showing increasing concentrations of antagonist in a FLIPR assay (approximate IC50 value 0.82 μM).

 

nAChR α4β2 - SyncroPatch Assay

nAChR assayFigure 3: nAChR α4β2 response to agonist in presence & absence of DHβE using SyncroPatch 384.

 

nAChR α4β2 - SyncroPatch Assay

nAChR assayFigure 4: EC50 plot showing increasing concentrations of agonist in a SyncroPatch assay (approximate EC50 value 4.2 μM).

Back to Family
Request a Screening Quote