Nav1.1 assay

Nav1.1 Screening Assays

Species: Human

Subunits / Accessory Proteins: Beta 1

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

Nav1.1 - Manual Patch Clamp

Nav1.1 assay

Figure 1: Current-Voltage relationship of INa expressed in terms of absolute current (pA), in the presence and absence of 100 nM TTX.

Nav1.1 - Manual Patch Clamp

Nav1.1 assay

Figure 2: Concentration-dependent effects of TTX on INa currents (pA) obtained cells stable transfected with Nav1.1. Calculated IC50 2 nM.


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