Nav1.2 assay

Nav1.2 Screening Assays

Species: Human

Subunits / Accessory Proteins: Beta 1

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

Nav1.2 QPatch

Nav1.2 assay

Figure 1: Effect of TTX on Nav1.2 sodium current. Absolute sodium currents (pA) shown in the presence and absence of TTX (1μM).

Nav1.2 QPatch

Nav1.2 assay

Figure 2: Concentration-dependent effects of TTX on INa currents (pA) obtained from cells stably transfected with Nav 1.2. Calculated IC50 value 20 nM.


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