Nav1.4 assay

Nav1.4 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

Nav1.4 QPatch

Nav1.4 assayFigure 1: Effect of TTX on Nav1.4 sodium current. Absolute sodium currents (pA) shown in the presence and absence of TTX (1μM).

Nav1.4 QPatch

Nav1.4 assayFigure 2: Concentration-dependent effects of TTX on INa currents (pA) obtained from HEK-293 cells stably transfected with Nav 1.4. Calculated IC50 value 34 nM.

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