Nav1.5 assay

Nav1.5 Screening Assays

Species: Human

Subunits / Accessory Proteins: Beta 1

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

Nav1.5 QPatch

Nav1.5 assay

Figure 1: Nav1.5 time-course experiment. Plotted graph expressed as current (nA) versus time (s) showing block of current induced by increasing concentrations of TTX.

Nav1.5 QPatch

Nav1.5 assay

Figure 2: Concentration-dependent effect of TTX on INa currents (pA) obtained from cells stably transfected with human NaV1.5 channels. IC50 value 4.8 μM.


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