Nav1.6 assay

Nav1.6 Screening Assays

Species: Human

Subunits / Accessory Proteins: Beta 1

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, Automated Electrophysiology

Services: HTS, single concentration / dose response studies, selectivity profiling

Nav1.6 QPatch

Nav1.6 assay

Figure 1: Representative time-course experiment recorded from Nav1.6 cells showing block of current induced by increasing concentrations of TTX.

Nav1.6 QPatch

Nav1.6 assay

Figure 2: Concentration-dependent effect of TTX on INa currents (pA) obtained from HEK-293 cells stably transfected with Nav1.6.

Nav1.6 SyncroPatch

Nav1.6 assay

Figure 3: Concentration-dependent effect of TTX on INa currents (pA) obtained from HEK-293 cells stably transfected with Nav1.6.

Nav1.6 SyncroPatch

Nav1.6 assay

Figure 4: Concentration-dependent effect of TTX on INa currents (pA) obtained from HEK-293 cells stably transfected with Nav1.6. Calculated IC50 value 1.2 nM.


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