Nav1.7 assay

Nav1.7 Screening Assays

Species: Human

Subunits / Accessory Proteins: Beta 1

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

Nav1.7 Manual Patch Clamp

Nav1.7 assay

Figure 1: Averaged activation current data used to plot  steady-state activation curve. The mid-point of activation value (Vh1/2) was approximately -29 mV.

Nav1.7 Manual Patch Clamp

Nav1.7 assay

Figure 2: Concentration-dependent effect of TTX on INa currents (pA) obtained from HEK-293 cells stable transfected with Nav1.7. Calculated IC50 value 26 nM.


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