Nav1.8 assay

Nav1.8 Screening Assays

Species: Human

Subunits / Accessory Proteins: Beta 3

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp

Services: HTS, single concentration / dose response studies, selectivity profiling

Nav1.8 - Manual Patch Clamp

Nav1.8 assay

Figure 1: Current-Voltage relationship of INa expressed in terms of absolute current (pA), in the absence and in the presence of TTX.

Nav1.8 - Manual Patch Clamp

Nav1.8 assay

Figure 2: Concentration-dependent effect of TTX on INa currents (pA) obtained from HEK-293 cells stably transfected with Nav1.8. Calculated IC50 45 μM.


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