Ion Channel Assays

NMDA (NR1/2A) Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK293

Assay Platforms: Fluorescence, Manual Patch Clamp, Automated Electrophysiology

Services: HTS, single concentration / dose response studies, selectivity profiling

NMDA NR1/2A - Fluorescence Assay

nmda assay

Figure 1:  Concentration dependent effect of agonist Glutamate (co-applied with Glycine). Calculated EC50 value approximately 546 nM.

NMDA NR1/2A - Fluorescence Assay

nmda assay

Figure 2: Concentration dependent effect of antagonist MK-801. Calculated IC50 value approximately 96 nM.


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