Ion Channel Assays

NMDA (NR1/2B) Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK293

Assay Platforms: Fluorescence, Manual Patch Clamp

Services: HTS, single concentration / dose response studies, selectivity profiling

NMDA NR1/2B - Manual Patch Clamp

nmda assay

Figure 1:  Concentration dependent effect of agonist Glutamate (co-applied with 10 µM Glycine). Calculated EC50 value approximately 2.4 µM.

NMDA NR1/2B - Manual Patch Clamp

nmda assay

Figure 2: Concentration dependent effect of antagonist MK-801. Calculated IC50 value approximately 6.2 nM.


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