Other Assays

bromodomain Assays

Species: Human

Subtypes: BAZ2B, BRM, CBP, BRD2(B1), BRD2(B2), BRD2(B1+B2), BRD4(B1), BRD4(B2) (others available on request)

Assay Format: TR-FRET

Services: IC50 determination

 

BAZ2B

Bromodomain assay

Figure 1: Dose response curve of H3 against BAZ2B in a TR-FRET assay.  IC50 89 nM. 

 

BRM

Bromodomain assay

Figure 2: Dose response curve of H3 against BRM in a TR-FRET assay.  IC50 1.25 μM. 

 

CBP

Bromodomain assay

Figure 3: Dose response curve of H4 against CBP in a TR-FRET assay.  IC50 256 nM. 

 

BRD2(B1)

Bromodomain assay

Figure 4: Dose response curve of (+)-JQ1 against BRD2 bromodomain 1 in a TR-FRET assay.  IC50 336 nM. 

 

BRD2(B2)

Bromodomain assay

Figure 5: Dose response curve of (+)-JQ1 against BRD2 bromodomain 2 in a TR-FRET assay.  IC50 62 nM. 

 

BRD2(B1+B2)

Bromodomain assay

Figure 6: Dose response curve of (+)-JQ1 against BRD2 bromodomains 1 and 2 in a TR-FRET assay.  IC50 820 nM. 

 

BRD4(B1)

Bromodomain assay

Figure 7: Dose response curve of (+)-JQ1 against BRD4 bromodomain 1 in a TR-FRET assay.  IC50 338 nM. 

 

BRD4(B2)

Bromodomain assay

Figure 8: Dose response curve of (+)-JQ1 against BRD4 bromodomain 2 in a TR-FRET assay.  IC50 239 nM. 


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