Other Assays

Cytochrome P450 Assays

Species: Human

Subtypes: CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP3A4 (others available on request)

Assay Format: Luminogenic CYP assay

Services: IC50 determination

 

CYP1A2

CYP assay

Figure 1: Concentration dependent block of CYP1A2 activity by a-napthoflavone. Calculated IC50 123 nM.

 

CYP2C9

CYP assay

Figure 2: Concentration dependent block of CYP2C9 activity by sulfaphenazole. Calculated IC50 87 nM.

 

CYP2C19

CYP assay

Figure 3: Concentration dependent block of CYP2C19 activity by miconazole. Calculated IC50 17 nM.

 

CYP2D6

CYP assay

Figure 4: Concentration dependent block of CYP2D6 activity by quinidine. Calculated IC50 11 nM.

 

CYP3A4

CYP assay

Figure 5: Concentration dependent block of CYP3A4 activity by ketoconazole. Calculated IC50 33 nM.


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