P2X Channels

P2X1 Screening Assays

Species:Human

Subunits / Accessory Proteins: N/A

Cell Type: 132N1 Astrocytoma

Assay Platforms: Fluorescence, Manual Patch Clamp

Services: HTS, single concentration / dose response studies, selectivity profiling

P2X1 - Manual Patch Clamp

P2X1 assay

Figure 1: Concentration-dependent effects of Bz-ATP obtained from 132N1 cells stably transfected with human P2X1 channels. Calculated EC50 value approximately 21.7nM.

P2X1 - Manual Patch Clamp

P2X1 assay

Figure 2:  Concentration-dependent effects of suramin obtained from 132N1 cells stably transfected with human P2X1 channels. Calculated IC50 value approximately 103μM.


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