P2X Channels

P2X4 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK293

Assay Platforms: Fluorescence, Manual Patch Clamp

Services: HTS, single concentration / dose response studies, selectivity profiling

P2X4 - Manual Patch Clamp

P2X4 assay

Figure 1: Normalised concentration-response curve of ATP against P2X4 channels. Calculated EC50 value 0.8 µM.

P2X4 - Manual Patch Clamp

P2X4 assay

Figure 2: Inhibitory effect of antagonist BX 430 (10 µM) on ATP-induced activation obtained from HEK-293 cells stably expressing P2X4 channels.


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