PDE Assays

PDE1 assays

Species: Human, Rat, Monkey

Human Isoforms Available: 1CAT, 1A3, 1B, 1C

Source: Recombinant, expressed in insect cells

Assay Formats: IMAP, Radiometric

Services: HTS, IC50 determination, selectivity profiling

PDE1 isoforms

PDE1 assay

Figure 1: Inhibition profile of sildenafil against PDE1 isoforms in a radiometric PDE assay.

Rat PDE1

PDE1 assay

Figure 2: Inhibition profile of sildenafil against rat PDE1 in a radiometric PDE assay.

 

Monkey PDE1

PDE1 assay

Figure 3: Inhibition profile of sildenafil against monkey PDE1 in a radiometric PDE assay.


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