PDE Assays

PDE4 assays

Species: Human, Mouse, Rat, Guinea Pig, Ferret, Dog, Monkey

Human Isoforms Available: 4A1, 4A4, 4A10, 4BCAT, 4B1, 4B2, 4B3, 4C2, 4D1, 4D2, 4D3, 4D4, 4D5, 4D7

Source: Recombinant, expressed in insect cells

Assay Formats: IMAP, Radiometric

Services: HTS, IC50 determination, selectivity profiling

PDE4A isoforms

PDE4A assay

Figure 1: Inhibition profile of rolipram against PDE4A isoforms in a radiometric PDE assay.

PDE4B isoforms

PDE4B assay

Figure 2: Inhibition profile of rolipram against PDE4B isoforms in a radiometric PDE assay.

PDE4C isoforms

PDE4C assay

Figure 3: Inhibition profile of rolipram against PDE4C2 in a radiometric PDE assay.

PDE4D isoforms

PDE4D assay

Figure 4: Inhibition profile of rolipram against PDE4D isoforms in a radiometric PDE assay.

Mouse PDE4

PDE4 assay

Figure 5: Inhibition profile of rolipram against mouse PDE4CAT in a radiometric PDE assay.

Rat PDE4

PDE4 assay

Figure 6: Inhibition profile of rolipram against rat PDE4CAT in a radiometric PDE assay.

Guinea Pig PDE4

PDE4 assay

Figure 7: Inhibition profile of rolipram against guinea pig PDE4CAT in a radiometric PDE assay.

Ferret PDE4

PDE4 assay

Figure 8: Inhibition profile of rolipram against ferret PDE4CAT in a radiometric PDE assay.

Dog PDE4

PDE4 assay

Figure 9: Inhibition profile of rolipram against dog PDE4CAT in a radiometric PDE assay.

Monkey PDE4

PDE4 assay

Figure 10: Inhibition profile of rolipram against monkey PDE4CAT in a radiometric PDE assay.


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