Inward Rectifier Potassium Channels

Inward Rectifier Potassium Channel Assays

Kir ion channels

Inwardly rectifying potassium (Kir) channels are a group of seven subfamilies of potassium channel which allow potassium to move more easily into rather than out of the cell. These channels can be divided into four functional groupings, classical Kir channels (Kir2.x) which are are constitutively active, G protein-gated Kir channels (Kir3.x) which are regulated by G protein-coupled receptors, ATP-sensitive K+ channels (Kir6.x) which are tightly linked to cellular metabolism, and K+ transport channels (Kir1.x, Kir4.x, Kir5.x, and Kir7.x). Kir channels possess diverse physiological functions depending on their type and tissue location and their dysfunction has been linked to a variety of diverse pathologies.

SB Drug Discovery offers a selection of Kir channel assays for HTS, lead optimization studies and selectivity profiling. Our assays have been validated by experienced in-house electrophysiologists using rigorously optimized SOPs to ensure data of the highest quality and consistency.


Fluorescence Assays

Kir ion channel assays

High throughput screening: SB offers high throughput screening assays using 96 & 384 well FLIPR platforms.

 

Kir ion channel assays

Selectivity profiling: FLIPR assays can be used to determine selectivity between closely related channels.

Electrophysiology

Kir2.1 electrophysiology
Kir2.1 electrophysiology

Potassium channel inward rectifier electrophysiology: Inward rectifier assays performed on the high throughput automated electrophysiology platform (SyncroPatch).


Inward Rectifier (Kir) Ion Channel Assays

Kir 2.1 Kir 2.2 Kir 2.4
Kir 4.1 Kir 4.1 / 5.1  

To discuss your next ion channel project or to receive a quote, visit our contact page or call +44 141 587 6100.


Ion channel cell lines
Ion channel screening