voltage gated potassium channels

Voltage-Gated Potassium Channels

voltage gated potassium channels

Potassium channels are the most widely distributed type of ion channel and are present on almost every cell type. Potassium channels can be divided into 4 main classes: voltage-gated (Kv), inwardly rectifying (Kir), tandem-pore domain (K2P) and calcium-activated (KCa). Of particular importance in the field of drug safety are the voltage-gated potassium channels Kv11.1 (hERG) and Kv7.1 (KCNQ1) which are associated with the potentially fatal Long QT Syndrome.

SB Drug Discovery offers a range of potassium channel assays for screening & profiling. A number of potassium channels are also included in SB's safety assessment panel. Our assays have been validated by experienced in-house electrophysiologists using rigorously optimized SOPs to ensure data of the highest quality and consistency.


Fluorescence Assays

potassium ion channel screening

Potassium channel screening: High throughput screening assays using 96 & 384-well FLIPR platforms.

 

potassium ion channel screening

Hit-to-lead profiling: Routine dose-response studies & selectivity assays for medicinal chemistry campaigns.

 

Electrophysiology Studies

 
 

High Quality Assays

Kv ion channel screening

Potassium channel stability: SB's potassium channel assays exhibit highly stable currents and display excellent reproducibility.

Stable Recordings

potassium ion channel screening

Potassium channel stability: SB's potassium channel assays exhibit highly stable currents and display excellent reproducibility.

High Throughput Electrophysiology

Potassium channel screening

High throughput potassium channel screening: 384-well high throughput electrophysiology assays designed and customized to meet your needs.


Voltage-Gated Potassium Channel Assays

Kv 1.3 Kv 1.5 Kv 2.1 Kv 2.1/9.3
Kv 2.2 Kv 3.1 Kv 3.2 Kv 3.3
Kv 3.4 Kv 4.3 Kv 4.3 / kChIP Kv 7.1
Kv 7.1 / minK Kv 7.2 Kv 7.2 / 7.3 Kv 11.1

To discuss your next ion channel project or to receive a quote, visit our contact page or call +44 141 587 6100.


Ion channel cell lines
Ion channel screening