Potassium channel assays

Potassium Channel Screening Services

Potassium Channels

Potassium channels are the most widely distributed type of ion channel and are present on almost every cell type. Potassium channels can be divided into 4 main classes: voltage-gated (Kv), inwardly rectifying (Kir), tandem-pore domain (K2P) and calcium-activated (KCa). Of particular importance in the field of drug safety are the voltage-gated potassium channels Kv11.1 (hERG) and Kv7.1 (KCNQ1) which are associated with the potentially fatal Long QT Syndrome.

SB Drug Discovery offers a range of potassium channel assays for screening & profiling. A number of potassium channels are also included in SB's safety assessment panel. Our assays have been validated by experienced in-house electrophysiologists using rigorously optimized SOPs to ensure data of the highest quality and consistency.

To discuss your next ion channel project or to receive a quote, visit our contact page or call +44 141 587 6100.

Voltage-gated potassium channel assays

Channel Species Fluorescence Assay Electrophysiology Assay
Kv1.3 Human Green Dot Green Dot
Kv1.5 Human Green Dot Green Dot
Kv2.1 Human Green Dot Green Dot
Kv2.1/9.3 Human Green Dot Green Dot
Kv2.2 Human Green Dot Green Dot
Kv3.1 Human Green Dot Green Dot
Kv3.2 Human Green Dot Green Dot
Kv3.3 Human Green Dot Green Dot
Kv3.4 Human Green Dot Green Dot
Kv4.3 Human Green Dot Green Dot
Kv4.3/KChiP2 Human Green Dot Green Dot
Kv7.1 Human Green Dot Green Dot
Kv7.1/mink Human Green Dot Green Dot
Kv7.2 Human Green Dot Green Dot
Kv7.2/7.3 Human Green Dot Green Dot
Kv11.1 (hERG) Human Green Dot Green Dot

Inwardly rectifying potassium channel assays

Channel Species Fluorescence Assay Electrophysiology Assay
Kir2.1 Human Green Dot Green Dot
Kir2.2 Human Green Dot Green Dot
Kir2.4 Human Green Dot Green Dot
Kir4.1 Human Green Dot Green Dot

K2P channel assays

Channel Species Fluorescence Assay Electrophysiology Assay
K2P2.1 (TREK-1) Human Green Dot Green Dot
K2P3.1 (TASK-1) Human Orange Dot Green Dot
K2P4.1 (TRAAK)  Human  Green Dot Green Dot
K2P5.1 (TASK-2) human Orange Dot Green Dot
K2P9.1 (TASK-3) Human Orange Dot Green Dot
K2P10.1 (TREK-2)  Human  Orange Dot Green Dot
K2P13.1 (THIK-1)  Human  Orange Dot Green Dot
K2P18.1 (TRESK) Human Orange Dot Green Dot
K2P 18.1 (TRESK) Mouse Orange Dot Orange Dot
K2P 18.1 (TRESK) Rat Orange Dot Orange Dot

Calcium-activated potassium channel assays

Channel Species Fluorescence Assay Electrophysiology Assay
KCa1.1 Human Green Dot Green Dot
KCa2.1 Human Green Dot Green Dot
KCa2.2 Human Green Dot Green Dot
KCa2.3  Human Green Dot Green Dot
KCa3.1 Human Green Dot Green Dot
KCa4.1 Human Green Dot Green Dot