Safety Assessment

Safety Assessment Screening

Reducing costly safety-related attrition.

Identification of undesirable off-target effects is an essential process in any drug discovery campaign. In vitro pharmacological profiling against a broad panel of known potential hazards at an early stage in the discovery process can therefore aid decision-making in lead generation, lead optimization and candidate selection, resulting in significantly reduced downstream safety-related attrition.

SB’s safety assessment panel covers ion channel, GPCR and other target classes and provides a broad pharmacological profile of your compounds and their potential to cause adverse drug reactions. Our flexible service allows you to screen against the complete panel or select only the targets that matter to you.

Ion channel panel

Target Species Fluorescence Electrophysiology
hERG Human Green Dot Green Dot
Cav1.2 Human Green Dot Green Dot
Nav1.5 Human Green Dot Green Dot
KCNQ1/E1 Human Green Dot Green Dot
Kv4.3/KCHiP2 Human Green Dot Green Dot
Kir2.1 Human Green Dot Green Dot
NMDA Human Green Dot Green Dot
nAChR Human Green Dot Green Dot
GABA-A Human Green Dot Green Dot
5HT3A Human Green Dot Green Dot

GPCR panel

Receptor Species Ligand Binding Cell-Based Assay
AdoR A2a Human Green Dot Green Dot
Adrenergic α1A Human Green Dot Green Dot
Adrenergic α2A Human Green Dot Green Dot
Adrenergic β1 Human   Green Dot
Adrenergic β2 Human   Green Dot
Cannabinoid CB1 Human Green Dot Green Dot
Cannabinoid CB2 Human Green Dot Green Dot
Cholecystokinin A Human   Green Dot
Dopaminergic D1 Human Green Dot Green Dot
Dopaminergic D2 Human Green Dot Green Dot
Endothelin ETA Human   Green Dot
Histamine H1 Human   Green Dot
Histamine H2 Human   Green Dot
δ-type Opioid Human   Green Dot
κ-type Opioid Human   Green Dot
μ-type Opioid Human   Green Dot
Muscarinic M1 Human Green Dot Green Dot
Muscarinic M2 Human Green Dot Green Dot
Muscarinic M3 Human Green Dot Green Dot
Serotonin 5HT1A Human Green Dot Green Dot
Serotonin 5HT1B Human   Green Dot
Serotonin 5HT2A Human Green Dot Green Dot
Serotonin 5HT2B Human   Green Dot
Vasopressin V1A Human   Green Dot

Other safety targets

Target Species Assay Format
PDE 3A Human Radiometric
PDE 4D Human Radiometric
Androgen Receptor Human Radioligand binding
Glucocorticoid Receptor Human Radioligand binding
Cyclooxygenase 1 (COX1) Human Immunoassay
Cyclooxygenase 2 (COX2) Human Immunoassay

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