Potassium Channel Assays

K2P4.1 (TRAAK) Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

K2P4.1 - QPatch

TRAAK assay

Figure 1: Concentration-dependent effect of Riluzole on normalised currents (I/Imax) obtained from cells stably expressing K2P4.1 channels. Calculated EC50 approximately 174 µM.

K2P4.1 - QPatch

TRAAK assay

Figure 2: Concentration-dependent effect of BaCl2 on normalised currents (I/Imax) obtained from cells stably expressing hK2P4.1 channels. Calculated IC50 approximately 3 mM.


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