Potassium Channel Assays

K2P18.1 (TRESK) Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

K2P18.1 - Manual Patch Clamp

tresk assay

Figure 1: Concentration-dependent effects of TEA-Cl on normalized TRESK outward currents obtained from HEK-293 cells stably transfected with human K2P18.1.

K2P18.1 - Manual Patch Clamp

tresk assay

Figure 2: Concentration-dependent effects of BaCl2 on normalized TRESK outward currents obtained from HEK-293 cells stably transfected with human K2P18.1.

K2P18.1 - QPatch

tresk assay

Figure 3: Representative example of superimposed currents and voltage traces showing time-course of change induced by application of blocker TEA in SB-HEK-TRESK cell line.

K2P18.1 - QPatch

tresk assay

Figure 4: Representative example of a plotted time-course experiment showing the effect of increasing concentrations of TEA against the voltage-activated potassium outward currents.


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