TRP Channels

TRPC1 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

TRPC1 - Fluorescence Assay

trpc1 assay

Figure 1: Concentration-dependent activation of TRPC1 channels by calcium chloride. Calculated EC50 value approximately 7.3 mM.

TRPC1 - Fluorescence Assay

trpc1 assay

Figure 2: Concentration-dependent inhibition of TRPC1 channels by Gd3+. Calculated IC50 value approximately 27.8 μM.

 

TRPC1 - Manual Patch Clamp

trpc1 assay

Figure 3: Normalised concentration-response activation curve of lanthanum chloride against TRPC1 channels. Calculated EC50 value was approximately 0.2 µM.

 

TRPC1 - Manual Patch Clamp

trpc1 assay

Figure 4: Normalised concentration-response inhibition curve of lanthanum chloride against TRPC1 channels. Calculated IC50 value was approximately 207 µM.


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