TRP Channels

TRPC3 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

TRPC3 - Fluorescence Assay

trpc3 assay

Figure 1: Concentration-dependent activation of TRPC3 channels by carbachol. Calculated EC50 value approximately 40.5 μM.

TRPC3 - Fluorescence Assay

trpc3 assay

Figure 2: Concentration-dependent inhibition of TRPC3 channels by Pyr3. Calculated IC50 value approximately 953 nM.

 

TRPC3 - QPatch

trpc3 assay

Figure 3: Concentration-dependent effect of OAG on ITRPC3 currents (pA) obtained from cells stably transfected with TRPC3 channels. Calculated EC50 was approximately 18 µM.

 

TRPC3 - QPatch

trpc3 assay

Figure 4: Concentration-dependent effect of Lanthanum Chloride on cells stably transfected with TRPC3 channels. Calculated IC50 value approximately 15 µM.


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