TRP Channels

TRPC5/M2 Screening Assays

Species: Human

Subunits / Accessory Proteins: Muscarinic M2 receptor

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

 

TRPC5/M2 - QPatch

trpc5/M2 assay

Figure 1: Superimposed Current and voltage traces of the effect of increasing concentrations of M2 activator Carbachol on TRPC5 currents.  M2 blocker AFDX-116 fully blocked the Carbachol-induced TRPC5 current.

 

TRPC5/M2 - QPatch

trpc5/M2 assay

Figure 2: Normalised concentration-response curve of effect of M2 activator Carbachol on TRPC5. EC50 value approximately 0.37 µM.


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