TRP Channels

TRPC5 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: FLIPR, Manual Patch Clamp, Automated Patch Clamp

Services: HTS, single concentration / dose response studies, selectivity profiling

TRPC5 - Fluorescence Assay

trpc5 assay

Figure 1: Concentration-dependent activation of TRPC5 channels by carbachol. Calculated EC50 value 961 nM.

TRPC5 - Fluorescence Assay

trpc5 assay

Figure 2: Concentration-dependent inhibition of TRPC5 channels by ML204. Calculated IC50 value 1.83 μM.

 

TRPC5 - Manual Patch Clamp

trpc5 assay

Figure 3: Normalised concentration-response curve of rosiglitazone against TRPC5 currents activated by internal Ca2+. EC50 value 4.5 µM.

 

TRPC5 - Manual Patch Clamp

trpc5 assay

Figure 4: Normalised concentration-response curve of ML204 against TRPC5 currents activated by internal Ca2+. IC50 value 0.52 µM.


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