TRP Channels

TRPC6 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

TRPC6 - Fluorescence Assay

trpc6 assay

Figure 1: Concentration-dependent activation of TRPC6 channels by carbachol. Calculated EC50 value approximately 2.85 μM.

TRPC6 - Fluorescence Assay

trpc6 assay

Figure 2: Concentration-dependent inhibition of TRPC6 channels by ML204. Calculated IC50 value approximately 5.87 μM.

TRPC6 - Manual Patch Clamp

trpc6 assay

Figure 3: Normalised concentration-response activation curve of OAG against TRPC6 channels. Calculated EC50 value 6 µM.

TRPC6 - Manual Patch Clamp

trpc6 assay

Figure 4: Normalised concentration-response inhibition curve of La3+ against TRPC6 channels activated by OAG. Calculated IC50 value 312 µM.


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