TRP Channels

TRPM3 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp

Services: HTS, single concentration / dose response studies, selectivity profiling

TRPM3 - Fluorescence Assay

trpm3 assay

Figure 1: Concentration-dependent activation of TRPM3 channels by pregnanolone sulphate. Calculated EC50 value 8.29 μM.

TRPM3 - Fluorescence Assay

trpm3 assay

Figure 2: Concentration-dependent inhibition of TRPM3 channels by Lanthanum Chloride. Calculated IC50 value 1mM.

 

TRPM3 - Manual Patch Clamp

trpm3 assay

Figure 3: Concentration-dependent effect of pregnanolone sulphate on peak currents (ITRPM3) obtained from cells stably transfected with TRPM3.

 

TRPM3 - Manual Patch Clamp

TRPM3 assay

Figure 4: Concentration-dependent block by mefenamic acid (+ pregnanolone sulphate) on TRPM3 currents (ITRPM3) obtained from cells stably transfected with TRPM3.


Back to Family
Request a Screening Quote