TRP Channels

TRPV4 Screening Assays

Species: Human

Subunits / Accessory Proteins: N/A

Cell Type: HEK-293

Assay Platforms: Fluorescence, Manual Patch Clamp, QPatch

Services: HTS, single concentration / dose response studies, selectivity profiling

TRPV4 - Fluorescence Assay

trpv4 assay

Figure 1: Concentration-dependent activation of TRPV4 channels by RN1747. Calculated EC50 value 455 nM.

TRPV4 - Fluorescence Assay

trpv4 assay

Figure 2: Concentration-dependent inhibition of TRPV4 channels by ruthenium red. Calculated IC50 value 259 nM.

 

TRPV4 - Manual Patch Clamp

trpv4 assay

Figure 3: Normalised concentration-response curve of RN1747 against TRPV4. Calculated EC50 value 2 µM.

 

TRPV4 - Manual Patch Clamp

trpv4 assay

Figure 4: Normalised concentration-response curve of RN1734 against TRPV4. Calculated IC50 value 27 µM.


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