Introduction N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors composed of two glycine-binding GluN1 subunits (encoded by GRIN1 gene) in combination with two glutamate-binding GluN2 subunits (encoded by GRIN2A, GRIN2B, GRIN2C or GRIN2D genes)....
Introduction Neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease remain conditions with major unmet clinical needs. Abnormalities in the endosomal-autophagic-lysosomal system, progressive neurological dysfunction and regional neuronal loss...
Introduction CLC-Ka and CLC-Kb are members of the CLC family of chloride channels and transporters, crucial for maintaining chloride ion homeostasis across cell membranes. CLC-Ka is predominantly found in the thin ascending limb of Henle’s loop, while CLC-Kb is...
Electrophysiological Characterization of Functional and Pharmacological Effects of CLC-1 and CLC-2 Channel Activity Introduction The CLC family comprises of voltage-dependent cell surface chloride (Cl-) ion channels and intracellular Cl-/H+ transporters which perform...
Discover how our comprehensive GABAA receptor expertise and data-driven insights can expedite your CNS drug discovery research today. Introduction The majority of inhibitory neurotransmission in the brain is mediated by the binding of γ-aminobutyric acid (GABA) to the...
Discover how our comprehensive TRP channel expertise and data-driven insights can expedite your CNS drug discovery research today. Introduction Glucose-dependent insulinotropic polypeptide (GIP) receptor, a member of the G protein-coupled receptor (GPCR) family,...
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Introducing the backbone of cellular regulation: Big Potassium (BK) channels. These gatekeepers of ion flow orchestrate many pivotal functions across diverse tissues within the human body. Introduction BK channels, widely recognized as high-conductance voltage and...
