Drug Discovery Screening
Rapid solutions for hit identification
At Sygnature Discovery, our experienced cellular pharmacology scientists utilize a wide array of assay technologies to facilitate high-throughput screening, lead optimization, and selectivity profiling against a variety of target classes.
Our commitment to advancing drug discovery research is reflected in our expert innovative strategies in cell line generation, assay development, and drug discovery screening. With a focus on quality, speed, and tailored solutions for existing and novel targets, our goal is to progress your research seamlessly from concept to success.
Years of Experience
Ready to Assay Targets
Customer Projects
Cell Line Generation
An essential component of any drug discovery endeavour is the availability of robust, high-quality assays that generate reliable data, enabling you to make well-informed decisions and accelerate your research.
Stable cell lines play a crucial role in the development of high-quality assays. As specialists in custom cell line generation, our cell biology team offers a competitive advantage by providing rapid, cost-effective, and innovative solutions tailored to your specific targets, using the latest technologies to deliver optimal cell reagents.
Assay Development
Sygnature Discovery has a proven track record in developing and optimizing a comprehensive array of target-focussed assays and downstream screening cascades for a broad array of targets including ion channels, GPCRs and transporters to quickly enable identification of novel chemical matter. Combining biochemical and functional cell-based assays, Sygnature Discovery provides insight into compound activity using a range of binding, fluorescence, luminescence, and electrophysiological technologies.
High-Throughput Screening
Our screening team offers fast hit-finding solutions and helps identify new starting points for medicinal chemistry programs. Using either customer-supplied compound libraries or our in-house LeadFinder Library together with advanced compound tracking, dispensing and sophisticated endpoint readers we ensure robust data generation you can trust.
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Radioligand Binding
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Calcium Mobilization
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Membrane Potential
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Thalium Flux
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Electrophysiology
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Biosensors
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Reporter Assays
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Flow Cytometry
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HTRF
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ELISA
In-House Compound Libraries
The LeadFinder Library, consisting of 150,000 lead-like commercial compounds, is designed to accelerate hit discovery with chemically diverse compounds. Featuring 90,000 unique scaffolds and predominately brain-permeable low molecular weight molecules, the library is curated by experienced medicinal chemists to provide high-quality starting points for hit-to-led programs.
Compound Management System
Sygnature Discovery’s advanced Azenta compound management system provides seamless integration with our high-throughput screening capabilities. With the capacity to store over 2 million compounds under optimal conditions, including client-supplied libraries, this system ensures precise tracking from storage to assay. Its automated capabilities enhance hit-finding success for challenging targets and diverse screening strategies.
Integrated Drug Discovery
Sygnature Discovery combines premium cell biology and screening expertise with Sygnature Discovery’s integrated drug discovery capabilities. This collaborative approach serve as an adaptable extension of in-house research teams, guiding projects from hit identification to lead optimization. Advanced informatics ensure transparent communication and data sharing, enabling unified collaboration to achieve your drug discovery goals.
Drug Discovery Screening Services from Sygnature Discovery
Learn more about our
Ion Channel capabilities
Learn more about our
GPCR capabilities
Learn more about our
Transporter capabilities
Why Choose Sygnature Discovery?
precise, reliable data
Sygnature Discovery has a proven track record of delivering high quality data and insights to help clients quickly and efficiently discover novel therapeutics.
Experienced team
With over 20 years of experience, Sygnature Discovery’s team of experienced scientists has a unique expertise in accelerating drug discovery.
Customized Solutions
Recognizing that each drug discovery project is unique, Sygnature Discovery offers customized solutions to address specific challenges and goals. This flexibility allows clients to optimize their research efforts.
State of the Art Facilities
Sygnature Discovery’s state-of-the-art facilities and equipment enable them to generate high quality data that can help clients quickly advance their research.
Contact Syganture Discovery
To learn more about our services or to request a quote.
Sygnature Discovery's Cellular Pharmacology Case Studies
Discover how our clients have achieved remarkable success with our innovative solutions. Explore our case studies to learn how we've helped businesses like yours overcome challenges and drive growth.
