Ion Channel Drug Discovery
Driving Ion Channel Drug Discovery Research
Discover tailored solutions with Sygnature Discovery, expertly adapted to your unique needs
We recognize that our clients have varied and intricate ion channel research requirements. That is why we offer a flexible and innovative range of drug discovery solutions that include an extensive collection of ion channel screening and electrophysiology assays as well as customizable cell line generation capabilities, utilizing state-of-the-art technologies.
End-to-end ion channel screening services
Target
Development
- Expression validation
- Cell line generation
- Assay development
High-Throughput
Screening
- 96/384-well format
- Fluorescence assays
- Automated electrophysiology
HIT Verification/
lead optimization
- Dose-response studies
- Routine screening
- Selectivity profiling
Leading technologies for rapid, reliable results
Fluorescence-Based Screening
We provide high-throughput ion channel screening using 96- and 384-well formats. Our platform supports a wide range of assay endpoints, including calcium flux, membrane potential and thallium flux, across an extensive panel of validated targets to enable efficient, flexible screening campaigns.
Electrophysiology Studies
Our 384-well automated patch clamp electrophysiology platforms support high-throughput screening and lead optimization profiling. These include solid-supported membrane-based systems, enabling efficient and scalable electrophysiology across a wide range of ion channel targets.
Manual Patch Electrophysiology
To complement our high-throughput screening and automated electrophysiology services, we employ classical manual and two-electrode voltage clamp techniques. These methods support mechanistic studies, channel characterization and heterometic subunit investigations for complex ion channel systems.
Ion Channel Case Studies
Here is a list of our Ion Channel Case Studies click on a title to view the full case study.
